Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.5
USERS' SCORE
Moderately Good
Based on 26 Reviews
7.8
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Vitamin B12 (as Methylcobalamin)
1,500 mcg
62500%
Top Medical Research Studies
9
We focused on whether white button mushrooms could help lower cholesterol levels and blood sugar in rats. In our study, we found that after three weeks of the mushroom powder, diabetic rats showed significant drops in glucose and triglyceride levels.
Furthermore, in hypercholesterolemic rats, a four-week treatment led to impressive reductions in total cholesterol and LDL cholesterol. Overall, these findings suggest that white button mushrooms may have beneficial effects on cholesterol and blood sugar management, at least in rat models.
Furthermore, in hypercholesterolemic rats, a four-week treatment led to impressive reductions in total cholesterol and LDL cholesterol. Overall, these findings suggest that white button mushrooms may have beneficial effects on cholesterol and blood sugar management, at least in rat models.
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7
We examined the effects of Secholex, an anion-exchange gel, on high cholesterol in 46 patients with severe hyperlipoproteinemia over various studies. The results revealed that Secholex effectively lowered cholesterol levels, achieving a 15% reduction after the first year and 13% during the second year. While it was less effective than cholestyramine in increasing bile acid excretion, many patients preferred Secholex. However, it’s important to note that a third of patients experienced limited reductions in cholesterol, indicating varying responses.
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9
We explored the effects of partial ileal bypass (PIB) on cholesterol levels in a small group of young adults with hyperlipidemia. After the surgical procedure, participants received vitamin B12 injections twice monthly.
Impressively, total plasma cholesterol levels decreased significantly three months after surgery and remained lower after one year. However, while PIB helped normalize cholesterol, it didn't completely prevent the progression of atherosclerosis in some patients. This indicates that while B12 treatment benefited cholesterol levels, it wasn't a cure-all for other cardiovascular issues we studied.
Impressively, total plasma cholesterol levels decreased significantly three months after surgery and remained lower after one year. However, while PIB helped normalize cholesterol, it didn't completely prevent the progression of atherosclerosis in some patients. This indicates that while B12 treatment benefited cholesterol levels, it wasn't a cure-all for other cardiovascular issues we studied.
Read More
Most Useful Reviews
7.5
Dizziness improved
15 people found this helpful
It's working! I bought this because my father had a cerebral infarction which affected his blood circulation and made him feel lightheaded. I wasn't expecting much, but my father, who used to suffer from dizziness, has reported significant improvement and appears to be sleeping better. I've sent it a few times and it seems to be effective.
Read More
9
Numbness alleviated
9 people found this helpful
Highly recommended! I'm very satisfied. I suffered from severe numbness in my fingertips and feet, and began using this vitamin B12 supplement as it was much cheaper than the medicine I was given. Remarkably, my numbness has almost disappeared. If you have similar issues, I suggest checking your blood circulation.
Read More
7.5
Neuralgia improved
6 people found this helpful
The effect on improving neuralgia is remarkable! I recently overcame shingles, but the neuralgia persisted. I found this vitamin B12 without magnesium stearate or silicon dioxide. After over a month of taking it, the discomfort from the neuralgia has significantly improved.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.5
- All Researches
9
We explored how a specific dietary supplement that includes Vitamin B12 affects cholesterol levels in individuals with moderate high cholesterol. In our study, 80 participants were split into a treatment group and a control group.
After 6 months, the group taking the supplement experienced a notable drop in total cholesterol (TC) and improvements in other cholesterol types, while the control group showed no significant changes outside of TC reduction.
This suggests that, while a healthy diet and exercise can help, the addition of such supplements, including Vitamin B12, may enhance cholesterol management more effectively.
After 6 months, the group taking the supplement experienced a notable drop in total cholesterol (TC) and improvements in other cholesterol types, while the control group showed no significant changes outside of TC reduction.
This suggests that, while a healthy diet and exercise can help, the addition of such supplements, including Vitamin B12, may enhance cholesterol management more effectively.
Read More
9
We focused on whether white button mushrooms could help lower cholesterol levels and blood sugar in rats. In our study, we found that after three weeks of the mushroom powder, diabetic rats showed significant drops in glucose and triglyceride levels.
Furthermore, in hypercholesterolemic rats, a four-week treatment led to impressive reductions in total cholesterol and LDL cholesterol. Overall, these findings suggest that white button mushrooms may have beneficial effects on cholesterol and blood sugar management, at least in rat models.
Furthermore, in hypercholesterolemic rats, a four-week treatment led to impressive reductions in total cholesterol and LDL cholesterol. Overall, these findings suggest that white button mushrooms may have beneficial effects on cholesterol and blood sugar management, at least in rat models.
Read More
9
We explored the effects of partial ileal bypass (PIB) on cholesterol levels in a small group of young adults with hyperlipidemia. After the surgical procedure, participants received vitamin B12 injections twice monthly.
Impressively, total plasma cholesterol levels decreased significantly three months after surgery and remained lower after one year. However, while PIB helped normalize cholesterol, it didn't completely prevent the progression of atherosclerosis in some patients. This indicates that while B12 treatment benefited cholesterol levels, it wasn't a cure-all for other cardiovascular issues we studied.
Impressively, total plasma cholesterol levels decreased significantly three months after surgery and remained lower after one year. However, while PIB helped normalize cholesterol, it didn't completely prevent the progression of atherosclerosis in some patients. This indicates that while B12 treatment benefited cholesterol levels, it wasn't a cure-all for other cardiovascular issues we studied.
Read More
8
We explored the effects of vitamins B12, B6, and folic acid on cholesterol and homocysteine levels in 24 male patients with high triglycerides and cholesterol issues. Over 120 days, patients took specific doses of these vitamins while researchers measured their lipid and homocysteine levels at various intervals.
While we saw a notable decrease in homocysteine levels and triglycerides, high-density lipoprotein (HDL) did increase slightly. However, overall cholesterol levels did not significantly change.
This suggests that while vitamin B supplementation can affect certain lipids and lower homocysteine, it may not drastically alter cholesterol levels in these patients.
While we saw a notable decrease in homocysteine levels and triglycerides, high-density lipoprotein (HDL) did increase slightly. However, overall cholesterol levels did not significantly change.
This suggests that while vitamin B supplementation can affect certain lipids and lower homocysteine, it may not drastically alter cholesterol levels in these patients.
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8
We explored how adding plant sterols to orange juice can impact cholesterol levels in mildly hypercholesterolemic individuals. In this study, 72 healthy participants enjoyed either regular orange juice or a fortified version for eight weeks.
Those drinking the fortified juice saw a decrease in total cholesterol by 7.2%, LDL cholesterol by 12.4%, and non-HDL cholesterol by 7.8%. However, we found no changes in HDL cholesterol or triglyceride levels. The results suggest that plant sterol-fortified orange juice can be a simple addition to a cholesterol-lowering diet.
Those drinking the fortified juice saw a decrease in total cholesterol by 7.2%, LDL cholesterol by 12.4%, and non-HDL cholesterol by 7.8%. However, we found no changes in HDL cholesterol or triglyceride levels. The results suggest that plant sterol-fortified orange juice can be a simple addition to a cholesterol-lowering diet.
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User Reviews
USERS' SCORE
Moderately Good
Based on 26 Reviews
7.8
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Dizziness improved
15 people found this helpful
It's working! I bought this because my father had a cerebral infarction which affected his blood circulation and made him feel lightheaded. I wasn't expecting much, but my father, who used to suffer from dizziness, has reported significant improvement and appears to be sleeping better. I've sent it a few times and it seems to be effective.
Read More
9
Numbness alleviated
9 people found this helpful
Highly recommended! I'm very satisfied. I suffered from severe numbness in my fingertips and feet, and began using this vitamin B12 supplement as it was much cheaper than the medicine I was given. Remarkably, my numbness has almost disappeared. If you have similar issues, I suggest checking your blood circulation.
Read More
7.5
Neuralgia improved
6 people found this helpful
The effect on improving neuralgia is remarkable! I recently overcame shingles, but the neuralgia persisted. I found this vitamin B12 without magnesium stearate or silicon dioxide. After over a month of taking it, the discomfort from the neuralgia has significantly improved.
Read More
10
Effective B12 source
5 people found this helpful
I had a severe B12 deficiency and had previously tried regular B12 supplements and injections with little success. A new doctor advised me to switch to Active B12, recommending the Doctors Best brand. After the blood test, my B12 levels rose above the at-risk threshold. I am very satisfied with these results and trust the ingredient quality of the Doctor Best line.
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6
Numbness reduced
5 people found this helpful
Very easy to drink! This vitamin B12 supplement is essential for repairing peripheral nerves. It's a small capsule, making it easy to take, even for those who dislike taking supplements. Since I've started taking it, my numbness has decreased, and I feel my dizziness and lightheadedness have reduced as well. I highly recommend this supplement!
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Frequently Asked Questions
6
Pain relief
8 people found this helpful
This vitamin B12 supplement has excellent quality and fast delivery. I purchased it on my doctor’s advice post-coronavirus due to constant chest pain. The capsules are convenient, and after a week of taking them, my back pain improved significantly. The quality is excellent, and I feel energised.
7.5
Numbness improvement
11 people found this helpful
After surgery, I experienced numbness, which led me to take this vitamin sceptically. To my surprise, the numbness significantly improved by the third day of use. The capsules are small and easy to swallow, made from high-quality ingredients. I still take it occasionally for back pain and limb numbness. Between cyanocobalamin and methylcobalamin, I found methylcobalamin to be more effective.
7.5
Neuralgia improved
6 people found this helpful
The effect on improving neuralgia is remarkable! I recently overcame shingles, but the neuralgia persisted. I found this vitamin B12 without magnesium stearate or silicon dioxide. After over a month of taking it, the discomfort from the neuralgia has significantly improved.
9
Stability improved
3 people found this helpful
Literally saved my health. More than five years of vegetarianism have brought both benefits and issues. My memory began to deteriorate, nails to break, and hair growth was poor. The doctor advised adding B12 to my diet. Almost immediately after starting, I noticed improvements—drowsiness and fatigue vanished, and my overall activity increased.
7.5
Dizziness improved
15 people found this helpful
It's working! I bought this because my father had a cerebral infarction which affected his blood circulation and made him feel lightheaded. I wasn't expecting much, but my father, who used to suffer from dizziness, has reported significant improvement and appears to be sleeping better. I've sent it a few times and it seems to be effective.
9
Effective supplement
11 people found this helpful
Methycobal is an active vitamin B12 supplement equivalent to prescription Methycobalamin. Unlike cyanocobalamin, it has a high absorption rate. This supplement helped alleviate my post-herpetic neuralgia significantly.
9
Numbness alleviated
9 people found this helpful
Highly recommended! I'm very satisfied. I suffered from severe numbness in my fingertips and feet, and began using this vitamin B12 supplement as it was much cheaper than the medicine I was given. Remarkably, my numbness has almost disappeared. If you have similar issues, I suggest checking your blood circulation.
6
Anemia relief
4 people found this helpful
Maybe it worked for my back pain and general fatigue due to anemia linked to my high cholesterol and improved blood sugar levels from a medication I started last year. Although I was taking Ferrochel Iron, I suspected a B12 deficiency, prompting me to try this supplement in March. My back pain improved significantly after I began using it, and I adopted moderate exercise. I still experience evening fatigue from the anemia, but I plan to use iron with folic acid moving forward.
6
Reduces nervousness
2 people found this helpful
This vitamin is crucial, just like other vitamins. I noticed a clear effect: it alleviated my nervousness and is particularly important for those on diabetes and cholesterol medications, as it mitigates their visual and auditory side effects. It's essential to gather more information about this!
7.5
Supports cholesterol levels
1 people found this helpful
Excellent! Vitamin B12, or Cobalamin, is vital for many bodily functions, such as normalising blood cholesterol levels and improving respiratory function. It reduces homocysteine, a risk factor for myocardial infarction. This vitamin also aids sleep, immune function, and even muscle gain while enhancing brain resilience to stress.
7.5
Maintains levels
1 people found this helpful
This highly effective vitamin B12 supplement is essential for monitoring blood vitamin levels. My parents use metformin year-round, so this B12 is vital for maintaining normal levels. Vegetarians should also consider supplementation.
4
Skin issues noted
2 people found this helpful
Excellent product! After taking this supplement, my B12 levels shot up, indicating it works! However, the dose was too high and caused mild acne breakouts, so I now take it 2-3 times a week. It's essential to consult a doctor before taking new supplements to ensure the right dosage.
7
We examined a multi-ingredient supplement (MIS) featuring red yeast rice and omega-3 fatty acids to see how it impacts cholesterol levels in patients without cardiovascular disease.
In our pilot study involving 19 participants, we found that the MIS significantly reduced total cholesterol and LDL cholesterol levels. While those on the combined regimen of MIS and omega-3 saw a drop in triglycerides, the change wasn't significant, likely due to the small participant group.
Overall, the MIS shows promise in helping with cholesterol management and may improve patient compliance.
In our pilot study involving 19 participants, we found that the MIS significantly reduced total cholesterol and LDL cholesterol levels. While those on the combined regimen of MIS and omega-3 saw a drop in triglycerides, the change wasn't significant, likely due to the small participant group.
Overall, the MIS shows promise in helping with cholesterol management and may improve patient compliance.
9
We explored how a specific dietary supplement that includes Vitamin B12 affects cholesterol levels in individuals with moderate high cholesterol. In our study, 80 participants were split into a treatment group and a control group.
After 6 months, the group taking the supplement experienced a notable drop in total cholesterol (TC) and improvements in other cholesterol types, while the control group showed no significant changes outside of TC reduction.
This suggests that, while a healthy diet and exercise can help, the addition of such supplements, including Vitamin B12, may enhance cholesterol management more effectively.
After 6 months, the group taking the supplement experienced a notable drop in total cholesterol (TC) and improvements in other cholesterol types, while the control group showed no significant changes outside of TC reduction.
This suggests that, while a healthy diet and exercise can help, the addition of such supplements, including Vitamin B12, may enhance cholesterol management more effectively.
7
We investigated the impact of a whole food plant-based (WFPB) diet on cholesterol levels and body weight in a community setting. Participants followed this diet along with vitamin B supplementation and attended meetings over 12 weeks.
While we observed considerable weight loss in the WFPB group, the cholesterol reduction wasn't significantly different from standard care at six months, unless we excluded dropouts. However, at twelve months, we did see meaningful reductions in both BMI and cholesterol levels for the WFPB diet group.
Overall, the initiative showed promise for improving health without restricting energy intake or mandating exercise.
While we observed considerable weight loss in the WFPB group, the cholesterol reduction wasn't significantly different from standard care at six months, unless we excluded dropouts. However, at twelve months, we did see meaningful reductions in both BMI and cholesterol levels for the WFPB diet group.
Overall, the initiative showed promise for improving health without restricting energy intake or mandating exercise.
References
- Wright N, Wilson L, Smith M, Duncan B, McHugh P. The BROAD study: A randomised controlled trial using a whole food plant-based diet in the community for obesity, ischaemic heart disease or diabetes. Nutr Diabetes. 2017;7:e256. doi:10.1038/nutd.2017.3
- Hobbs T, Caso R, McMahon D, Nymark M. A novel, multi-ingredient supplement to manage elevated blood lipids in patients with no evidence of cardiovascular disease: a pilot study. Altern Ther Health Med. 2014;20:18.
- Lombardo F, Lunghi R, Pallotti F, Palumbo A, Senofonte G, et al. Effects of a dietary supplement on cholesterol in subjects with moderate hypercholesterolemia. Clin Ter. 2013;164:e147. doi:10.7417/CT.2013.1556
- Garaiova I, Muchová J, Nagyová Z, Mišľanová C, Oravec S, et al. Effect of a plant sterol, fish oil and B vitamin combination on cardiovascular risk factors in hypercholesterolemic children and adolescents: a pilot study. Nutr J. 2013;12:7. doi:10.1186/1475-2891-12-7
- Jeong SC, Jeong YT, Yang BK, Islam R, Koyyalamudi SR, et al. White button mushroom (Agaricus bisporus) lowers blood glucose and cholesterol levels in diabetic and hypercholesterolemic rats. Nutr Res. 2010;30:49. doi:10.1016/j.nutres.2009.12.003
- Morón de Salim AR, Garcés Pasamontes A. [Effect of the supplementation of vitamins B12, B6 and folic acid on homocysteine and plasmatic lipids in patients with hyperlipoproteinemic secondary type IV]. Arch Latinoam Nutr. 2005;55:28.
- Devaraj S, Jialal I, Vega-López S. Plant sterol-fortified orange juice effectively lowers cholesterol levels in mildly hypercholesterolemic healthy individuals. Arterioscler Thromb Vasc Biol. 2004;24:e25.
- MacMahon M, Kirkpatrick C, Cummings CE, Clayton A, Robinson PJ, et al. A pilot study with simvastatin and folic acid/vitamin B12 in preparation for the Study of the Effectiveness of Additional Reductions in Cholesterol and Homocysteine (SEARCH). Nutr Metab Cardiovasc Dis. 2000;10:195.
- Defraigne JO, Pirenne J, Swinnen JC, Honore P, Jacquet N, et al. [Value and limits of bypassing the distal ileum in the treatment of hypercholesterolemia]. J Chir (Paris). 1990;127:76.
- Nikkila EA, Miettinen TA, Lanner A. Treatment of hypercholesterolemia with Secholex. A long-term clinical trial and comparison with cholestyramine. Atherosclerosis. 1976;24:407.
